Как мы стареем

32 Glück, S., et al. 2017. “I

33 De Cecco, M., et al. 2019. “L1 Drives IFN in Senescent Cells and Promotes Age-Associated Inflammation”. Nature 566:73–78, https://doi.org/10.1038/s41586-018-0784-9.

34 Ermolaeva et al. 2013.

35 Coppé, J. P., Desprez, P. Y., Krtolica, A., Campisi, J. 2010. “The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression”. A

36 Terlecki-Zaniewicz, L., et al. 2018. “Small Extracellular Vesicles and Their miRNA Cargo Are Antiapoptotic Members of the Senescence-Associated Secretory Phenotype”. Aging (Albany NY) 10:1103–32, https://doi.org/10.18632/aging.101452.

37 Wiley, C. D., et al. 2017. “Analy sis of Individual Cells Identifies Cell-to-Cell Variability following Induction of Cellular Senescence”. Aging Cell 16:1043–50, https://doi.org/10.1111/acel.12632.

38 Zhu, Y., et al. 2015. “The Achilles’ Heel of Senescent Cells: From Transcriptome to Senolytic Drugs”. Aging Cell 14:644–58, https://doi.org/10.1111/acel.12344; Martel, J., et al. 2020. “Emerging Use of Senolytics and Senomorphics against Aging and Chronic Diseases”. Medicinal Research Reviews 40:2114–31, https://doi.org/10.1002/med.21702; Schafer, M. J., Haak, A. J., Tschumperlin, D. J., LeBrasseur, N. K. 2018. “Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations”. Current Rheumatology Reports 20:3, https://doi.org/10.1007/s11926-018-0712-x.

39 Jones, M. W., Brett, K., Han, N., Wyatt, H. A. 2021. “Hyperbaric Physics”. StatPearls. Treasure Island, FL: StatPearls.

40 Kamran, P., et al. 2013. “Parabiosis in Mice: A Detailed Protocol”. Journal of Visualized Experiments, no. 80, e50556, https://doi.org/10.3791/50556.

41 Kosoff, M. 2016. “Peter Thiel Wants to Inject Himself with Young People’s Blood”. Vanity Fair, August 1, 2016, https://www.vanityfair.com/news/2016/08/peter-thiel-wants-to-inject-himself-with-young-peoples-blood; Buhr, S. 2017. “No, Peter Thiel Is Not Harvesting the Blood of the Young”. TechCrunch, June 14, 2017, https://techcrunch.com/2017/06/14/ no peter-thiel-is-not-harvesting-the-blood-of-the-young/; Haynes, G. 2017. “Ambrosia: The Startup Harvesting the Blood of the Young”. Guardian, August 21, 2017, https://www.theguardian.com/society/shortcuts/2017/aug/21/ambrosia-the-startup-harvesting-the-blood-of-the-young; “The Blood Boy”. Silicon Valley, season 4, episode 5 (HBO, 2017).

42 Ludwig, F. C., Elashoff, R. M. 1972. “Mortality in Syngeneic Rat Parabionts of Different Chronological Age”. Transactions of the New York Academy of Sciences 34:582–87, https://doi.org/10.1111/j.2164–0947.1972.tb02712.x.

43 Wagers, A. J., Sherwood, R. I., Christensen, J. L., Weissman, I. L. 2002. “Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells”. Science 297:2256–59, https://doi.org/10.1126/science.1074807.

44 Conboy, I. M., et al. 2005. “Rejuvenation of Aged Progenitor Cells by Exposure to a Young Systemic Environment”. Nature 433:760–64, https://doi.org/10.1038/nature03260.

45 Zhang, B., et al. 2021. “Multi-omic Rejuvenation and Lifespan Extension upon Exposure to Youthful Circulation”. bioRxiv, 2021.11.11.468258, https://doi.org10.1101/2021.11.11.468258.

46 Loffredo, F. S., et al. 2013. “Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy”. Cell 153:828–39, https://doi.org/10.1016/j.cell.2013.04.015.

47 Elabd, C., et al. 2014. “Oxytocin Is an Age-Specific Circulating Hormone that Is Necessary for Muscle Maintenance and Regeneration”. Nature Communications 5:4082, https://doi.org/10.1038/ncomms5082; Saito, Y., et al. 1998. “Klotho Protein Protects against Endothelial Dysfunction”. Biochemical and Biophysical Research Communications 248:324–29, https://doi.org/10.1006/bbrc.1998.8943; Zhou, Y., et al. 2021. “Integration of FGF21 Signaling and Metabolomics in High-Fat Diet-Induced Obesity”. Journal of Proteome Research 20:3900–3912, https://doi.org/10.1021/acs.jproteome.1c00197.

48 Villeda, S. A., et al. 2011. “The Ageing Systemic Milieu Negatively Regulates Neurogenesis and Cognitive Function”. Nature 477:90–94, https://doi.org/10.1038/nature10357.

49 Villeda, S. A., et al. 2014. “Young Blood Reverses Age-Related Impairments in Cognitive Function and Synaptic Plasticity in Mice”. Nature Medicine 20:659–63, https://doi.org/10.1038/nm.3569.

50 Castellano, J. M., et al. 2017. “Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice”. Nature 544:488–92, https://doi.org/10.1038/nature220 67.

51 Horowitz, A. M., et al. 2020. “Blood Factors Transfer Beneficial Effects of Exercise on Neurogenesis and Cognition to the Aged Brain”. Science 369:167–73, https://doi.org/10.1126/science.aaw2622.

Глaвa 11. Используй или потеряешь

1 Kluger, J. 2013. “Too Old to Be a Dad?” Time, April 11, 2013, https://healthland.time.com/2013/04/11/too-old-to-be-a-dad/.

2 Shadyab, A. H., et al. 2017. “Maternal Age at Childbirth and Parity as Predictors of Longevity among Women in the United States: The Women’s Health Initiative”. American Journal of Public Health 107:113–19, https://doi.org/10.2105/AJPH.2016.303503.

3 Sun, F., et al. 2015. “Extended Maternal Age at Birth of Last Child and Women ’s Longevity in the Long Life Family Study”. Menopause 22:26–31, https://doi.org/10.1097/GME.0000000000000276.

4 Perls, T. T., Alpert, L., Fretts, R. C. 1997. “Middle-Aged Mothers Live Longer”. Nature 389:133, https://doi.org/10.1038/38148.

5 Fagan, E., et al. 2017. “Telomere Length Is Longer in Women with Late Maternal Age”. Menopause 24:497–501, https://doi.org/10.1097/GME.0000000000000795.

6 Steiner, A. Z., et al. 2017. “Association between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age”. JAMA 318:1367–76, https://doi.org/10.1001/jama.2017.14588.

7 Liss, J., et al. 2017. “Clinical Utility of Different Anti-Mullerian Hormone: AMH Assays for the Purpose of Pregnancy Prediction”. Gynecological Endocrinology 33:791–96, https://doi.org/10.1080/09513590.2017.1318370; Depma

8 Stolk, L., et al. 2012. “Meta-analyses Identify 13 Loci Associated with Age at Menopause and Highlight DNA Repair and Immune Pathways”. Nature Genetics 44:260–68, https://doi.org/10.1038/ng.1051; He, C., et al. 2009. “Genome-wide Association Studies Identify Loci Associated with Age at Menarche and Age at Natural Menopause”. Nature Genetics 41:724–28, https://doi.org/10.1038/ng.385; Stolk, L., et al. 2009. “Loci at Chromosomes 13, 19 and 20 Influence Age at Natural Menopause”. Nature Genetics 41:645–47, https://doi.org/10.1038/ng.387.

9 Ossewaarde, M. E., et al. 2005. “Age at Menopause, Cause-Specific Mortality and Total Life Expectancy”. Epidemiology 16:556–62, https://doi.org/10.1097/01.ede.0000165392.35273.d4.

10 Mills, P. K., Beeson, W. L., Phillips, R. L., Fraser, G. E. 1989. “Prospective Study of Exogenous Hormone Use and Breast Cancer in Seventh-Day Adventists”. Cancer 64:591–97, https://doi.org/10.1002/1097–0142 (19890801) 64:3<591::aid-cncr2820640305>3.0.co;2-u.

11 Levine, M. E., et al. 2016. “Menopause Accelerates Biological Aging”. Proceedings of the National Academy of Sciences of the USA 113:9327–32, https://doi.org/10.1073/pnas.1604558113.

12 Horvath, S., 2013. “DNA Methylation Age of Human Tissues and Cell Types”. Genome Biology 14: R115, https://doi.org/10.1186/gb-2013-14-10-r115.

13 Levine et al. 2016.

14 Levine et al. 2016.

15 Hsin, H., Kenyon, C. 1999. “Signals from the Reproductive System Regulate the Lifespan of C. elegans”. Nature 399:362–66.

16 Arantes-Oliveira, N., Apfeld, J., Dillin, A., Kenyon, C. 2002. “Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans”. Science 295:502–5.

17 Ghazi, A., Henis-Korenblit, S., Kenyon, C. 2009. “A Transcription Elongation Factor that Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans”. PLOS Genetics 5: e1000639, https://doi.org/10.1371/journal.pgen.1000639; Amrit, F. R. G., et al. 2019. “The Longevity-Promoting Factor, TCER-1, Widely Represses Stress Resistance and I

18 Shi, C., Booth, L. N., Murphy, C. T. 2019. “Insulin-like Peptides and the mTOR-TFEB Pathway Protect Caenorhabditis elegans Hermaphrodites from Mating-Induced Death”. eLife 8: e46413, https://doi.org/10.7554/eLife.46413; Lee, H. J., et al. 2019. “Prostaglandin Signals from Adult Germ Stem Cells Delay Somatic Aging of Caenorhabditis elegans”. Nature Metabolism 1:790–810, https://doi.org/10.1038/s42255-019-0097-9.

19 Flatt, T., et al. 2008. “Drosophila Germ-Line Modulation of Insulin Signaling and Lifespan”. Proceedings of the National Academy of Sciences of the USA 105:6368–73, https://doi.org/10.1073/pnas.0709128105.

20 Cargill, S. L., Carey, J. R., Muller, H. G., Anderson, G. 2003. “Age of Ovary Determines Remaining Life Expectancy in Old Ovariectomized Mice”. Aging Cell 2:185–90, https://doi.org/10.1046/j.1474–9728.2003.00049.x.

21 Min, K. J., Lee, C. K., Park, H. N. 2012. “The Lifespan of Korean Eunuchs”. Current Biology 22: R792–93, https://doi.org/10.1016/j.cub.2012.06.036; Le Bourg, E. 2015. “No Ground for Advocating that Korean Eunuchs Lived Longer than Intact Men”. Gerontology 62:69–70, https://doi.org/10.1159/000435854.

22 Jiang, Z., Shen, H. 2021. “Mitochondria: Emerging Therapeutic Strategies for Oocyte Rescue”. Reproductive Sciences, https://doi.org/10.1007/s43032-021-00523-4.

23 Cota, V., Murphy, C. T. 2021. “Fission and PINK-1-Mediated Mitophagy Are Required for Insulin/IGF-1 Signaling Mutant Reproductive Longevity”. bioRxiv, 2021.08.16.456566, https://doi.org/10.1101/2021.08.16.456566; Lesnik, C., Cota, V., Sohrabi, S., Murphy, C. T. “BCAA Metabolism Is Critical for Oocyte Quality” (MS, в печaти).