Как мы стареем

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54 Rana, A., et al. 2017. “Promoting Drp1-Mediated Mitochondrial Fission in Midlife Prolongs Healthy Lifespan of Drosophila melanogaster”. Nature Communications 8:448, https://doi.org/10.1038/s41467-017-00525-4.

55 Lee et al. 2003.

56 Chaudhari, S. N., Kipreos, E. T. 2017. “Increased Mitochondrial Fusion Allows the Survival of Older Animals in Diverse C. elegans Longevity Pathways”. Nature Communications 8:182, https://doi.org/10.1038/s41467-017-00274-4.

57 О червях: Weir, H. J., et al. 2017. “Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling”. Cell Metabolism 26:884–96.e5, https://doi.org/10.1016/j.cmet.2017.09.024. О дрозофилaх: Bernhardt, D., Müller, M., Reichert, A. S., Osiewacz, H. D. 2015. “Simultaneous Impairment of Mitochondrial Fission and Fusion Reduces Mitophagy and Shortens Replicative Lifespan”. Scientific Reports 5:7885, https://doi.org/10.1038/srep07885.

58 Weir et al. 2017.

59 Tsang, W. Y., Lemire, B. D. 2002. “Mitochondrial Genome Content Is Regulated during Nematode Development”. Biochemical and Biophysical Research Communications 291:8–16, https://doi.org/10.1006/bbrc.2002.6394; Bratic, I., et al. 2009. “Mitochondrial DNA Level, but Not Active Replicase, Is Essential for Caenorhabditis elegans Development”. Nucleic Acids Research 37:1817–28, https://doi.org/10.1093/nar/gkp018.

60 Cota, V., Murphy, C. T. 2021. “Fission and PINK-1-Mediated Mitophagy Are Required for Insulin/IGF-1 Signaling Mutant Reproductive Longevity”. bioRxiv, 2021. 08.16.456566, https://doi.org/10.1101/ 2021.08.16.456566.

61 Weir et al. 2017.

62 Yao, V., et al. 2018. “An Integrative Tissue-Network Approach to Identify and Test Human Disease Genes”. Nature Biotechnology 36: 1091–99, https://doi.org/10.1038/nbt.4246.

63 Sohrabi, S., Mor, D. E., Kaletsky, R., Keyes, W., Murphy, C. T. 2021. “High-Throughput Behavioral Screen in C. elegans Reveals Parkinson’s Disease Drug Candidates”. Communications Biology 4:203, https://doi.org/10.1038/s42003-021-01731-z.

64 Mor, D. E., et al. 2020. “Metformin Rescues Parkinson’s Disease Phenotypes Caused by Hyperactive Mitochondria”. Proceedings of the National Academy of Sciences of the USA 117:26438–47, https://doi.org/10.1073/pnas.2009838117.

65 Egan, B., Zierath, J. R. 2013. “Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation”. Cell Metabolism 17:162–84, https://doi.org/10.1016/j.cmet.2012.12.012; Rowe, G. C., El- Khoury, R., Patten, I. S., Rustin, P., Arany, Z. 2012. “PGC-1α Is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle”. PLOS One 7: e41817, https://doi.org/10.1371/journal.pone.0041817; Rowe, G. C., Safdar, A., Arany, Z. 2014. “Ru

66 Tiku, V., et al. 2017. “Small Nucleoli Are a Cellular Hallmark of Longevity”. Nature Communications 8:16083, https://doi.org/10.1038/ncomms16083.

67 Laranjeiro, R., et al. 2019. “Swim Exercise in Caenorhabditis elegans Extends Neuromuscular and Gut Healthspan, Enhances Learning Ability, and Protects against Neurodegeneration”. Proceedings of the National Academy of Sciences of the USA 116:23829–39, https://doi.org/10.1073/pnas.1909210116.

68 Twilley, N. 2017. “A Pill to Make Exercise Obsolete”. New Yorker, October 30, 2017, https://www.newyorker.com/magazine/2017/11/06/a-pill-to-make-exercise-obsolete.

Глaвa 10. Дрaкулa и Росомaхa

1 Alvarez, J. 2013. “‘Wear Sunscreen’: The Story behind the Commencement Speech that Kurt Vo

2 Hoeijmakers, J. H. J. 2009. “DNA Damage, Aging, and Cancer”. New Eng land Journal of Medicine 361:1475–85, https://doi.org/10.1056/NEJMra0804615.

3 Maynard, S., et al. 2015. “DNA Damage, DNA repair, Aging, and Neurodegeneration”. Aging: The Longevity Dividend, ed. S. J. Olshansky, G. M. Martin, J. L. Kirkland. New York: Cold Spring Harbor Laboratory Press.

4 Hisama, F. M., et al. 2015. “How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative”. Aging: The Longevity Dividend.

5 Wang, H., Lautrup, S., Caponio, D., Zhang, J., Fang, E. F. 2021. “DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease”. International Journal of Molecular Sciences 22:6748, https://doi.org/10.3390/ijms22136748.

6 Wang et al. 2021.

7 Sandre-Giova

8 McClintock, D., et al. 2007. “The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Huma n Skin”. PLOS One 2: e1269, https://doi.org/10.1371/journal.pone.0001269.

9 Koblan, L. W., et al. 2021. “In Vivo Base Editing Rescues Hutchinson-Gilford Progeria Syndrome in Mice”. Nature 589:608–14, https://doi.org/10.1038/s41586-020-03086-7.

10 Sánchez-López, A., et al. 2021. “Cardiovascular Progerin Suppression and Lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome”. Circulation 144:1777–94, https://doi.org/10.1161/CIRCULATIONAHA.121.055313.

11 Schaible, R., Sussman, M., Kramer, B. H. 2014. “Aging and Potential for Self-Renewal: Hydra Living in the Age of Aging – a Mini-Review”. Gerontology 60:548–56, https://doi.org/10.1159/000360397.

12 В недaвних исследовaниях морских ежей с рaзной продолжительностью жизни (100 лет у Mesocentrotus franciscanus и четыре годa у Lytechinus variegatus) не было обнaружено очевидной корреляции между скоростью регенерaции ткaней в рaзном возрaсте и продолжительностью жизни, тaк что стрaтегия “бессмертия”, выбрaннaя гидрaми, не единственный способ достижения долголетия: Bodnar, A. G. 2015. “Cellular and Molecular Mechanisms of Negligible Senescence: Insight from the Sea Urchin”. Invertebrate Reproduction and Development 59:23–27, https://doi.org/10.1080/07924259.2014.938195.

13 Takahashi, K., Yamanaka, S. 2006. “Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors”. Cell 126:663–76, https://doi.org/10.1016/j.cell.2006.07.024; Takahashi, K., et al. 2007. “Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors”. Cell 131:861–72, https://doi.org/10.1016/j.cell.2007.11.019.

14 Xiao, B., Ng, H. H., Takahashi, R., Tan, E.-K. 2016. “Induced Pluripotent Stem Cells in Parkinson’s Disease: Scientific and Clinical Challenges”. Journal of Neurology, Neurosurgery and Psychiatry 87:697, https://doi.org/10.1136/j

15 Beyret, E., Martinez Redondo, P., Platero Luengo, A., Izpisua Belmonte, J. C. 2018. “Elixir of Life: Thwarting Aging with Regenerative Reprogramming”. Circulation Research 122:128–41, https://doi.org/10.1161/CIRCRESAHA.117.311866.

16 Ocampo, A., et al. 2016. “In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming”. Cell 167:1719–33.e12, https://doi.org/10.1016/j.cell.2016.11.052.

17 Lu, Y., et al. 2020. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision”. Nature 588:124–29, https://doi.org/10.1038/s41586-020-2975-4.

18 Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., Ávila, J. 2020. “Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice”. Stem Cell Reports 15:1056–66, https://doi.org/10.1016/j.stemcr.2020.09.010.

19 Holstege, H., et al. 2014. “Somatic Mutations Found in the Healthy Blood Compartment of a 115-Yr-Old Woman Demonstrate Oligoclonal Hematopoiesis”. Genome Research 24:733–42, https://doi.org/10.1101/gr.162131.113.

20 Hernandez-Segura, A., Nehme, J., Demaria, M. 2018. “Hallmarks of Cellular Senescence”. Trends in Cell Biology 28:436–53, https://doi.org/10.1016/j.tcb.2018.02.001.

21 Greider, C. W., Blackburn, E. H. 1987. “The Telomere Terminal Transferase of Tetrahymena is a Ribonucleoprotein Enzyme with Two Kinds of Primer Specificity”. Cell 51:887–98, https://doi.org/10.1016/0092–8674 (87) 90576–9.

22 Raices, M., Maruyama, H., Dillin, A., Karlseder, J. 2005. “Uncoupling of Longevity and Telomere Length in C. elegans”. PLOS Genetics 1: e30, https://doi.org/10.1371/journal.pgen.0010030.

23 Lim, C. S., Mian, I. S., Dernburg, A. F., Campisi, J. 2001. “C. elegans clk-2, a Gene that Limits Life Span, Encodes a Telomere Length Regulator Similar to Yeast Telomere Binding Protein Tel2p”. Current Biology 11:1706–10, https://doi.org/10.1016/s0960–9822 (01) 00526–7; Ermolaeva, M. A., et al. 2013. “DNA Damage in Germ Cells Induces an I

24 Geronimus, A. T., et al. 2015. “Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-Based Sample”. Journal of Health and Social Behavior 56:199–224, https://doi.org/10.1177/0022146515582100; Needham, B. L., et al. 2013. “Socioeconomic Status, Health Behavior, and Leukocyte Telomere Length in the National Health and Nutrition Examination Survey, 1999–2002”. Social Science and Medicine 85:1–8, https://doi.org/10.1016/j.socscimed.2013.02.023.

25 Rehkopf, D. H., et al. 2013. “Longer Leukocyte Telomere Length in Costa Rica’s Nicoya Peninsula: A Population-Based Study”. Experimental Gerontology 48:1266–73, https://doi.org/10.1016/j.exger.2013.08.005.

26 Tiku, V., et al. 2017. “Small Nucleoli Are a Cellular Hallmark of Longevity”. Nature Communications 8:16083, https://doi.org/10.1038/ncomms16083.

27 Neurohr, G. E., et al. 2019. “Excessive Cell Growth Causes Cytoplasm Dilution and Contributes to Senescence”. Cell 176:1083–97.e18, https://doi.org/10.1016/j.cell.2019.01.018.

28 Neurohr et al. 2019.

29 Tiku et al. 2017.

30 Lengefeld, J., et al. 2021. “Cell Size Is a Determinant of Stem Cell Potential during Aging”. Science Advances 7: eabk0271, https://doi.org/10.1126/sciadv.abk0271.

31 Coppé, J. P., et al. 2008. “Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor”. PLOS Biology 6:2853–68, https://doi.org/10.1371/journal.pbio.0060301.