Как мы стареем

24 Hamatani, T., et al. 2004. “Age-Associated Alteration of Gene Expression Patterns in Mouse Oocytes”. Human Molecular Genetics 13:2263–78; Steuerwald, N. M., Bermudez, M. G., Wells, D., Mu

25 Hughes, S. E., Evason, K., Xiong, C., Kornfeld, K. 2007. “Genetic and Pharmacological Factors that Influence Reproductive Aging in Nematodes”. PLOS Genetics 3: e25.

26 Luo, S., Kleema

27 Luo et al. 2010.

28 Hamatani et al. 2004.

29 Savage-Du

30 Luo, S., Shaw, W. M., Ashraf, J., Murphy, C. T. 2009. “TGF-Beta Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging”. PLOS Genetics 5: e1000789, https://doi.org/10.1371/journal.pgen.1000789.

31 Shaw, W. M., Luo, S., Landis, J., Ashraf, J., Murphy, C. T. 2007. “The C. elegans TGF-Beta Dauer Pathway Regulates Longevity via Insulin Signaling”. Current Biology 17:1635–45, https://doi.org/10.1016/j.cub.2007.08.058.

32 Huang, C., Xiong, C., Kornfeld, K. 2004. “Measurements of Age-Related Changes of Physiological Processes that Predict Lifespan of Caenorhabditis elegans”. Proceedings of the National Academy of Sciences of the USA 101:8084–89.

33 Luo et al. 2009.

34 Luo et al. 2010; Templeman, N. M., et al. 2018. “Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity”. Current Biology 28:753–60.e4, https://doi.org/10.1016/j.cub.2018.01.052.

35 Templeman et al. 2018.

36 Balboula, A. Z., et al. 2010. “Cathepsin B Activity Is Related to the Quality of Bovine Cumulus Oocyte Complexes and Its Inhibition Can Improve Their Developmental Competence”. Molecular Reproduction and Development 77:439–48, https://doi.org/10.1002/mrd.21164.

37 Perls, Alpert, Fretts 1997.

38 Hawkes, K. 2020. “The Centrality of Ancestral Grandmothering in Human Evolution”. Integrative and Comparative Biology 60:765–81, https://doi.org/10.1093/icb/icaa029. Интересно, что в пьесе Сaры Трим “Кaк и почему” (The How and the Why) рaсскaзывaется о двух женщинaх ученых, изучaющих влияние бaбушек.

39 Maliha, G., Murphy, C. T. 2016. “A Simple Offspring-to-Mother Size Ratio Predicts Post-reproductive Lifespan”. bioRxiv, 048835, https://doi.org/10.1101/048835.

40 Bodnar, A. G. 2015. “Cellular and Molecular Mechanisms of Negligible Senescence: Insight from the Sea Urchin”. Invertebrate Reproduction and Development 59:23–27, https://doi.org/10.1080/07924259.2014.938195.

41 Luo et al. 2009.

Глaвa 12. Секс, мухи (и черви) и видеозaписи

1 Интервью с Элизaбет Эриaс: Сокрaщение продолжительности жизни в 2020 г., CDC National Center for Health Statistics, February 19, 2021, https://www.cdc.gov/nchs/pressroom/podcasts/2021/20210219/20210219.htm.

2 Ostan, R., et al. 2016. “Gender, Aging and Longevity in Humans: An Update of an Intriguing/Neglected Scenario Paving the Way to a Gender-Specific Medicine”. Clinical Science (London) 130:1711–25, https://doi.org/10.1042/cs20160004.

3 Ostan et al. 2016; Jack, C. R., Jr., et al. 2015. “Age, Sex and APOE ε4 Effects on Memory, Brain Structure and β-amyloid across the Adult Lifespan”. JAMA Neurology 72:511–19, https://doi.org/10.1001/jamaneurol.2014.4821; Davis, E. J., et al. 2020. “A Second X Chromosome Contributes to Resilience in a Mouse Model of Alzheimer’s Disease”. Science Translational Medicine 12: eaaz5677, https://doi.org/10.1126/scitranslmed.aaz5677.

4 Zeng, Y., et al. 2018. “Sex Differences in Genetic Associations with Longevity”. JAMA Network Open 1: e181670, https://doi.org/10.1001/jamanetworkopen.2018.1670.

5 Anselmi, C. V., et al. 2009. “Association of theFOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study”. Rejuvenation Research 12:95–104, https://doi.org/10.1089/rej.2008.0827.

6 Gems, D. 2014. “Evolution of Sexually Dimorphic Longevity in Humans”. Aging (Albany NY) 6:84–91, https://doi.org/10.18632/aging.100640.

7 Hawkes, K. 2020. “The Centrality of Ancestral Grandmothering in Human Evolution”. Integrative and Comparative Biology 60:765–81, https://doi.org/10.1093/icb/icaa029.

8 Dobson, R. 2006. “The Stress of Marriage Shortens Your Life by a Year (if You’re the Wife)”. Independent, February 26, 2006, https://www.independent.co.uk/life-style/health-and-families/health-news/the-stress-of-marriage-shortens-your-life-by-a-year-if-youre-the-wife-5335547.html.

9 Ostan et al. 2016.

10 Jasienska, G., Nenko, I., Jasienski, M. 2006. “Daughters Increase Longevity of Fathers, but Daughters and Sons Equally Reduce Longevity of Mothers”. American Journal of Human Biology 18:422–25, https://doi.org/10.1002/ajhb.20497.

11 Adebowale, A. S. 2018. “Spousal Age Difference and Associated Predictors of Intimate Partner Violence in Nigeria”. BMC Public Health 18:212, https://doi.org/10.1186/s12889-0185118-1.

12 Metzler, S., Heinze, J., Schrempf, A. 2016. “Mating and Longevity in Ant Males”. Ecology and Evolution 6:8903–6, https://doi.org/10.1002/ece3.2474.

13 Becker, J. B., Prendergast, B. J., Liang, J. W. 2016. “Female Rats Are Not More Variable than Male Rats: A Meta-analysis of Neuroscience Studies”. Biology of Sex Differences 7:34, https://doi.org/10.1186/s13293-016-0087-5.

14 Becker, Prendergast, and Liang 2016.

15 Smarr, B., Kriegsfeld, L. J. 2022. “Female Mice Exhibit Less Overall Variance, with a Higher Proportion of Structured Variance, than Males at Multiple Timescales of Continuous Body Temperature and Locomotive Activity Records”. Biology of Sex Differences 13:41, https://doi.org/10.1186/s13293-022-00451-1.

16 Harrison, D. E., et al. 2014. “Acarbose, 17-α-estradiol, and Nordihydroguaiaretic Acid Extend Mouse Lifespan Preferentially in Males”. Aging Cell 13:273–82, https://doi.org/10.1111/acel.12170.

17 Kanfi, Y., et al. 2012. “The Sirtuin SIRT6 Regulates Lifespan in Male Mice”. Nature 483:218–21, https://doi.org/10.1038/nature10815.

18 Kanfi et al. 2012.

19 Kane, A. E., Sinclair, D. A., Mitchell, J. R., Mitchell, S. J. 2018. “Sex Differences in the Response to Dietary Restriction in Rodents”. Current Opinion in Physiology 6:28–34, https://doi.org/10.1016/j.cophys.2018.03.008.

20 Davis, E. J., Lobach, I., Dubal, D. B. 2019. “Female XX Sex Chromosomes Increase Survival and Extend Lifespan in Aging Mice”. Aging Cell 18: e12871, https://doi.org/10.1111/acel.12871.

21 Tower, J. 2006. “Sex-Specific Regulation of Aging and Apoptosis”. Mechanisms of Ageing and Development 127:705–18, https://doi.org/10.1016/j.mad.2006.05.001.

22 Garratt, M. 2020. “Why Do Sexes Differ in Lifespan Extension? Sex-Specific Pathways of Aging and Underlying Mechanisms for Dimorphic Responses”. Nutrition and Healthy Aging 5:247–59, https://doi.org/10.3233/NHA-190067; Clancy, D. J., et al. 2001. “Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein”. Science 292:104–6, https://doi.org/10.1126/science.1057991; Gia

23 Ryan, D. A., et al. 2014. “Sex, Age, and Hunger Regulate Behavioral Prioritization through Dynamic Modulation of Chemoreceptor Expression”. Current Biology 24:2509–17, https://doi.org/10.1016/j.cub.2014.09.032.

24 Gems, D., Riddle, D. L. 2000. “Genetic, Behavioral and Environmental Determinants of Male Longevity in Caenorhabditis elegans”. Genetics 154:1597–1610.

25 Klass, M. R. 1983. “A Method for the Isolation of Longevity Mutants in the Nematode Caenorhabditis elegans and Initial Results”. Mechanisms of Ageing and Development 22:279–86, https://doi.org/10.1016/0047–6374 (83) 90082–9.

26 Shi, C., Ru

27 Hsin, H., Kenyon, C. 1999. “Signals from the Reproductive System Regulate the Lifespan of C. elegans”. Nature 399:362–66.

28 McCulloch, D., Gems, D. 2003. “Evolution of Male Longevity Bias in Nematodes”. Aging Cell 2:165–73, https://doi.org/10.1046/j.1474–9728.2003.00047.x.

29 Lee, S. J., Murphy, C. T., Kenyon, C. 2009. “Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression”. Cell Metabolism 10:379–91, https://doi.org/10.1016/j.cmet.2009.10.003; Liggett, M. R., Hoy, M. J., Mastroia

30 Honjoh, S., Ihara, A., Kajiwara, Y., Yamamoto, T., Nishida, E. 2017. “The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans”. Cell Reports 21:3646–52, https://doi.org/10.1016/j.celrep.2017.11.108.

31 Honjoh et al. 2017.

32 Garrison, J. L., et al. 2012. “Oxytocin/Vasopressin-Related Peptides Have an Ancient Role in Reproductive Behavior”. Science 338:540–43, https://doi.org/10.1126/science.1226201.

33 Fetter-Pruneda, I., et al. 2021. “An Oxytocin/Vasopressin-Related Neuropeptide Modulates Social Foraging Behavior in the Clonal Raider Ant”. PLOS Biology 19: e3001305, https://doi.org/10.1371/journal.pbio.3001305.

34 Shi, C., Ru

35 Headland, M., Clifton, P. M., Carter, S., Keogh, J. B. 2016. “Weight-Loss Outcomes: A Systematic Review and Meta-analysis of Intermittent Energy Restriction Trials Lasting a Minimum of 6 Months”. Nutrients 8:354, https://doi.org/10.3390/nu8060354.

36 Headland et al. 2016.