Как мы стареем

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20 Kirkwood, T. B. 1987. “Immortality of the Germ-Line versus Disposability of the Soma”. Basic Life Sciences 42:209–18.

21 Min, K. J., Lee, C. K., Park, H. N. 2012. “The Lifespan of Korean Eunuchs”. Current Biology 22: R792–93, https://doi.org/10.1016/j.cub.2012.06.036.

22 Le Bourg, E. 2015. “No Ground for Advocating that Korean Eunuchs Lived Longer than Intact Men”. Gerontology 62:69–70, https://doi.org/10.1159/000435854.

23 Hsin, H., Kenyon, C. 1999. “Signals from the Reproductive System Regulate the Lifespan of C. elegans”. Nature 399:362–66.

24 Shi, C., Booth, L. N., Murphy, C. T. 2019. “Insulin-like Peptides and the mTOR-TFEB Pathway Protect Caenorhabditis elegans Hermaphrodites from Mating-Induced Death”. eLife 8, https://doi.org/10.7554/eLife.46413; Shi, C., Murphy, C. T. 2014. “Mating Induces Shrinking and Death in Caenorhabditis Mothers”. Science 343:536–40, https://doi.org/10.1126/science.1242958; Shi, C., Ru

25 Dillin, A., Crawford, D. K., Kenyon, C. 2002. “Timing Requirements for Insulin/IGF-1 Signaling in C. elegans”. Science 298:830–34.

26 Venz, R., Pekec, T., Katic, I., Ciosk, R., Ewald, C. Y. 2021. “End-of-Life Targeted Auxin-Mediated Degradation of DAF-2 Insulin/IGF-1 Receptor Promotes Longevity Free from Growth-Related Pathologies”. eLife 10: e71335, https://doi.org/10.7554/eLife.71335.

27 Sohrabi, S., Cota, V., Murphy, C. T. 2023. “CeLab, a Microfluidic Platform for the Study of Life History Traits, Reveals Metformin and SGK-1 Regulation of Longevity and Reproductive Span”. bioRxiv, 2023.01.09.523184, https://doi.org/10.1101/2023.01.09.523184.

28 Perls, T. T., Alpert, L., Fretts, R. C. 1997. “Middle-Aged Mothers Live Longer”. Nature 389:133, https://doi.org/10.1038/38148.

29 Обзор многих из этих теорий можно нaйти здесь: “Biological Aging Theories” (Programmed-Aging.org, последняя версия 2015, http://www.programmed-aging.org/theories/).

30 Mitteldorf, J., Pepper, J. 2009. “Senescence as an Adaptation to Limit the Spread of Disease”. Journal of Theoretical Biology 260:186–95, https://doi.org/10.1016/j.jtbi.2009.05.013.

31 Mitteldorf, J., Pepper, J. W. 2007. “How Can Evolutionary Theory Accommodate Recent Empirical Results on Organismal Senescence?” Theory in Biosciences 126:3–8, https://doi.org/10.1007/s12064-007-0001-0.

32 Brunet-Rossi

33 Turbill, C., Bieber, C., Ruf, T. 2011. “Hibernation Is Associated with Increased Survival and the Evolution of Slow Life Histories among Mammals”. Proceedings of the Royal Society B: Biological Sciences 278:3355–63, https://doi.org/10.1098/rspb.2011.0190.

34 Godfrey-Smith, P. 2016. “Octopuses and the Puzzle of Aging”. New York Times, December 2, 2016.

35 Reznick, D., Bryant, M., Holmes, D. 2006. “The Evolution of Senescence and Post-reproductive Lifespan in Guppies (Poecilia reticulata)”. PLOS Biology 4: e7, https://doi.org/10.1371/journal.pbio.0040007.

36 Carroll, S. B. 2016. The Serengeti Rules: The Quest to Discover How Life Works and Why It Matters. Princeton, NJ: Princeton University Press.

37 Hawkes, K. 2003. “Grandmothers and the Evolution of Human Longevity”. American Journal of Human Biology 15:380–400, https://doi.org/10.1002/ajhb.10156.

38 Maliha, G., Murphy, C. T. 2016. “A Simple Offspring-to-Mother Size Ratio Predicts Post-reproductive Lifespan”. bioRxiv, 048835, https://doi.org/10.1101/048835.

39 Francis, N., Gregg, T., Owen, R., Ebert, T., Bodnar, A. 2006. “Lack of Age-Associated Telomere Shortening in Long- and Short-Lived Species of Sea Urchins”. FEBS Letters 580:4713–17, https://doi.org/10.1016/j.febslet.2006.07.049.

40 Giaimo, S., Baudisch, A. 2015. “The Effect of Post-Reproductive Lifespan on the Fixation Probability of Beneficial Mutations”. PLOS One 10: e0133820, https://doi.org/10.1371/journal.pone.0133820.

41 Mao, K., et al. 2018. “Late-Life Targeting of the IGF-1 Receptor Improves Healthspan and Lifespan in Female Mice”. Nature Communications 9:2394, https://doi.org/10.1038/s41467-018-04805-5.

42 Laron, Z. 2002. “Effects of Growth Hormone and Insulin-like Growth Factor 1 Deficiency on Ageing and Longevity”. Novartis Foundation Symposium 242:125–37; обсуждение 137–42.

43 Suh, Y., et al. 2008. “Functionally Significant Insulin-like Growth Factor I Receptor Mutations in Centenarians”. Proceedings of the National Academy of Sciences of the USA 105:3438–42.

44 Dobzhansky, T. 1973. “Nothing in Biology Makes Sense Except in the Light of Evolution”. American Biology Teacher 35:125–29, https://doi.org/10.2307/4444260.

Глaвa 3. Генетикa долгожительствa у человекa

1 Zak, N. 2019. “Evidence that Jea

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3 Lenart, A., Vaupel, J. W. 2017. “Questionable Evidence for a Limit to Human Lifespan”. Nature 546: E13–14, https://doi.org/10.1038/nature22790.

4 Rozing, M. P., Kirkwood, T. B. L., Westendorp, R. G. J. 2017. “Is There Evidence for a Limit to Human Lifespan?” Nature 546: E11–12, https://doi.org/10.1038/nature22788.

5 Barbi, E., Lagona, F., Marsili, M., Vaupel, J. W., Wachter, K. W. 2018. “The Plateau of Human Mortality: Demography of Longevity Pioneers”. Science 360:1459–61, https://doi.org/10.1126/science.aat3119.

6 Ismail, K., et al. 2016. “Compression of Morbidity Is Observed across Cohorts with Exceptional Longevity”. Journal of the American Geriatrics Society 64, 1583–91, https://doi.org/10.1111/jgs.14222.

7 Fries, J. F. 1980. “Aging, Natural Death, and the Compression of Morbidity”. New England Journal of Medicine 303:130–35, https://doi.org/10.1056/NEJM198007173030304.

8 Buettner, D., Skemp, S. 2016. “Blue Zones: Lessons From the World’s Longest Lived”. American Journal of Lifestyle Medicine 10:318–21, https://doi.org/10.1177/1559827616637066; Poulain, M., et al. 2004. “Identification of a Geographic Area Characterized by Extreme Longevity in the Sardinia Island: The AKEA Study”. Experimental Gerontology 39:1423–29, https://doi.org/10.1016/j.exger.2004.06.016.

9 Buettner, D. 2012. The Blue Zones: 9 Lessons for Living Longer from the People Who’ve Lived the Longest, 2nd ed. Washington, DC: National Geographic.

10 Herskind, A. M., et al. 1996. “The Heritability of Human Longevity: A Population-Based Study of 2872 Danish Twin Pairs Born 1870–1900”. Human Genetics 97:319–23; Yashin, A. I., Iachine, I. A., Harris, J. R. 1999. “Half of Variation in Susceptibility to Mortality is Genetic: Findings from Swedish Twin Survival Data”. Behavior Genetics 29:11–19; Christensen, K., Johnson, T. E., Vaupel, J. W., 2006. “The Quest for Genetic Determinants of Human Longevity: Challenges and Insights”. Nature Reviews Genetics 7:436–48; Willcox, B. J., Willcox, D. C., Suzuki, M. 2017. “Demographic, Phenotypic, and Genetic Characteristics of Centenarians in Okinawa and Japan: Part 1, Centenarians in Okinawa”. Mechanisms of Ageing and Development 165:75–79, https://doi.org/10.1016/j.mad.2016.11.001.

11 Deelen, J., et al. 2019. “A Meta-analysis of Genome-wide Association Studies Identifies Multiple Longevity Genes”. Nature Communications 10:3669, https://doi.org/10.1038/s41467-019-11, 558–2.

12 Milman, S., Barzilai, N. 2015. “Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span”. Aging: The Longevity Dividend, ed. S. J. Olshansky, G. M. Martin, J. L. Kirkland. New York: Cold Spring Harbor Laboratory Press, 93.

13 Sebastiani, P., Perls, T. T. 2012. “The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study”. Frontiers in Genetics 3:277, https://doi.org/10.3389/fgene.2012.00277.

14 Joshi, P. K., et al. 2017. “Genome-wide Meta-analysis Associates HLA-DQA1/DRB1 and LPA and Lifestyle Factors with Human Longevity”. Nature Communications 8:910, https:// doi.org/10.1038/s41467-017-00934-5.

15 Nygaard, M., Thinggaard, M., Christensen, K., Christiansen, L. 2017. “Investigation of the 5q33.3 Longevity Locus and Age-Related Phenotypes”. Aging (Albany NY) 9:247–55, https://doi.org/10.18632/aging.101156.

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17 Sanders, A. E., et al. 2010. “Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene with Memory Decline and Incidence of Dementia”. JAMA 303:150–58, https://doi.org/10.1001/jama.2009.1988.