Как мы стареем

18 О немaтодaх C. elegans: Henderson, S. T., Johnson, T. E. 2001. “daf-16 Integrates Developmental and Environmental Inputs to Mediate Aging in the Nematode Caenorhabditis elegans”. Current Biology 11:1975–80; Lin, K., Dorman, J. B., Rodan, A., Kenyon, C. 1997. “daf-16: An HNF-3/Forkhead Family Member that Can Function to Double the Life-Span of Caenorhabditis elegans”. Science 278:1319–22; Ogg, S., et al. 1997. “The Fork Head Transcription Factor DAF-16 Transduces Insulin-like Metabolic and Longevity Signals in C. elegans”. Nature 389:994–99. О дрозофилaх: Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M., Tatar, M. 2004. “Drosophila dFOXO Controls Lifespan and Regulates Insulin Signalling in Brain and Fat Body”. Nature 429:562–66; Gia

19 Willcox, B. J., et al. 2008. “FOXO3A Genotype Is Strongly Associated with Human Longevity”. Proceedings of the National Academy of Sciences of the USA 105:13987–92, https://doi.org/10.1073/pnas.0801030105; Anselmi, C. V., et al. 2009. “Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study”. Rejuvenation Research 12:95–104, https://doi.org/10.1089/rej.2008.0827; Flachsbart, F., et al. 2009. “Association of FOXO3A Variation with Human Longevity Confirmed in German Centenarians”. Proceedings of the National Academy of Sciences of the USA 106:2700–2705, https://doi.org/10.1073/pnas.0809594106.

20 Suh, Y., et al. 2008. “Functionally Significant Insulin-like Growth Factor I Receptor Mutations in Centenarians”. Proceedings of the National Academy of Science s of the USA 105:3438–42.

21 Teumer, A., et al. 2016. “Genomewide Meta-analysis Identifies Loci Associated with IGF-I and IGFBP-3 Levels with Impact on Age-Related Traits”. Aging Cell 15:811–24, https:// doi.org/10.1111/acel.12490.

22 Joshi et al. 2017.

23 Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M., Kroemer, G. 2013. “The Hallmarks of Aging”. Cell 153:1194–217, https://doi.org/10.1016/j.cell.2013.05.039.

24 Joshi et al. 2017.

25 Andriani, G. A., et al. 2016. “Whole Chromosome Instability Induces Senescence and Promotes SASP”. Scientific Reports 6:35218, https://doi.org/10.1038/srep35218.

26 Zeng, Y., et al. 2016. “Novel Loci and Pathways Significantly Associated with Longevity”. Scientific Reports 6:21243, https://doi.org/10.1038/srep21243.

27 Zeng, Y., et al. 2016. “Interaction between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages”. Rejuvenation Research 19, 195–203, https://doi.org/10.1089/rej.2015.1737.

28 Harmon, A. 2017. “The Secret to Long Life? It May Lurk in the DNA of the Oldest among Us”. New York Times, November 13, 2017, https://www.nytimes.com/2017/11/13/health/supercentenarians-genetics-longevity.html.

29 Betterhumans Inc. “Collaborate with Betterhumans”. Betterhumans Supercentenarian Research Study, 2022, https://supercentenarianstudy.com/collaborate.html.

30 Garagnani, P., et al. 2021. “Whole-Genome Sequencing Analy sis of Semi- supercentenarians”. eLife 10: e57849, https://doi.org/10.7554/eLife.57849.

31 Teumer et al. 2016; Johnson, S. C., Dong, X., Vijg, J., Suh, Y. 2015. “Genetic Evidence for Common Pathways in Human Age-Related Diseases”. Aging Cell 14:809–17, https://doi.org/10.1111/acel.12362.

32 Fortney, K., et al. 2015. “Genome-wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity”. PLOS Genetics 11: e1005728, https://doi.org/10.1371/journal.pgen.1005728.

33 Ruby, J. G., et al. 2018. “Estimates of the Heritability of Human Longevity Are Substantially Inflated Due to Assortative Mating”. Genetics 210:1109–24, https://doi.org/10.1534/genetics.118.301613.

Глaвa 4. Долгоживущие оргaнизмы и долгоживущие мутaнты модельных оргaнизмов

1 Austad, S. N. 2005. “Diverse Aging Rates in Metazoans: Targets for Functional Genomics”. Mechanisms of Ageing and Development 126:43–49, https://doi.org/10.1016/j.mad.2004.09.022.

2 Barber, E. 2013. “Scientists Discover World’s Oldest Clam, Killing It in the Process”. Christian Science Monitor, November 15, 2013, https://www.csmonitor.com/Science/2013/1115/Scientists-discover-worlds-oldest-clam-killing-it-in-the-process.

3 Nielsen, J., et al. 2016. “Eye Lens Radiocarbon Reveals Centuries of Longevity in the Greenland Shark (Somniosus microcephalus)”. Science 353:702–4, https://doi.org/10.1126/science.aaf1703.

4 Atwal, S. 2022. “190-Year-Old Jonathan Becomes World’s Oldest Tortoise Ever”. Gui

5 Keane, M., et al. 2015. “Insights into the Evolution of Longevity from the Bowhead Whale Genome”. Cell Reports 10:112–22, https://doi.org/10.1016/j.celrep.2014.12.008.

6 Laron, Z. 2002. “Effects of Growth Hormone and Insulin-like Growth Factor 1 Deficiency on Ageing and Longevity”. Novartis Foundation Symposium 242:125–37; discussion 137–42.

7 Rosenbloom, A. L., Aguirre, J. G., Rosenfeld, R. G., Fielder, P. J. 1990. “The Little Women of Loja: Growth Hormone – Receptor Deficiency in an Inbred Population of Southern Ecuador”. New England Journal of Medicine 323:1367–74, https://doi.org/10.1056/nejm199011153232002.

8 Austad, S. N., Fischer, K. E. 1991. “Mammalian Aging, Metabolism, and Ecology: Evidence from the Bats and Marsupials”. Journal of Gerontology 46: B47–53, https://doi.org/10.1093/geronj/46.2. B47.

9 Turbill, C., Smith, S., Deimel, C., Ruf, T. 2012. “Daily Torpor Is Associated with Telomere Length Change over Winter in Djungarian Hamsters”. Biology Letters 8:304–7, https://doi.org/10.1098/rsbl.2011.0758.

10 Foley, N. M., et al. 2018. “Growing Old, Yet Staying Young: The Role of Telomeres in Bats’ Exceptional Longevity”. Science Advances 4: eaao0926, https://doi.org/10.1126/sciadv.aao0926; Zhang, G., et al. 2013. “Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity”. Science 339:456–60, https://doi.org/10.1126/science.1230835.

11 Seim, I., et al. 2013. “Genome Analy sis Reveals Insights into Physiology and Longevity of the Brandt’s Bat Myotis brandtii”. Nature Communications 4:2212, https://doi.org/10.1038/ncomms3212.

12 Lewis, K. N., Andziak, B., Yang, T., Buffenstein, R. 2013. “The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It”. Antioxidants and Redox Signaling 19:1388–99, https://doi.org/10.1089/ars.2012.4911.

13 Buffenstein, R. 2008. “Negligible Senescence in the Longest Living Rodent, the Naked Mole-Rat: Insights from a Successfully Aging Species”. Journal of Comparative Physiology B 178:439–45, https://doi.org/10.1007/s00360-007-0237-5.

14 Zhao, Y., et al. 2018. “Naked Mole Rats Can Undergo Developmental, Oncogene-Induced and DNA Damage-Induced Cellular Senescence”. Proceedings of the National Academy of Sciences of the USA 115:1801–6, https://doi.org/10.1073/pnas.1721160115.

15 Lee, B. P., Smith, M., Buffenstein, R., Harries, L. W. 2020. “Negligible Senescence in Naked Mole Rats May Be a Consequence of Well-Maintained Splicing Regulation”. Geroscience 42:633–651, https://doi.org/10.1007/s11357-019-00150-7.

16 Lewis, K. N., et al. 2016. “Unraveling the Message: Insights into Comparative Genomics of the Naked Mole-Rat”. Mammalian Genome 27:259–78, https://doi.org/10.1007/s00335-016-9648-5.

17 Kim, E. B., et al. 2011. “Genome Sequencing Reveals Insights into Physiology and Longevity of the Naked Mole Rat”. Nature 479:223–27, https://doi.org/10.1038/nature10533.

18 Tian, X., et al. 2013. “High-Molecular-Mass Hyaluronan Mediates the Cancer Resistance of the Naked Mole Rat”. Nature 499:346–49, https://doi.org/10.1038/nature12234.

19 О регуляции инсулиновых сигнaльных путей: Ihle, K. E., Baker, N. A., Amdam, G. V. 2014. “Insulin-like Peptide Response to Nutritional Input in Honey Bee Workers”. Journal of Insect Physiology 69:49–55, https://doi.org/10.1016/j.jinsphys.2014.05.026.

20 Hutchinson, E. W., Shaw, A. J., Rose, M. R. 1991. “Quantitative Genetics of Postponed Aging in Drosophila melanogaster: II, Analysis of Selected Lines”. Genetics 127:729–37, https://doi.org/10.1093/genetics/127.4.729; Leroi, A. M., Chen, W. R., and Rose, M. R. 1994. “Long-Term Laboratory Evolution of a Genetic Life-History Trade-off in Drosophila melanogaster: 2, Stability of Genetic Correlations”. Evolution 48:1258–68, https://doi.org/10.1111/j.1558–5646.1994.tb05310.x.

21 Chapman, T., Liddle, L. F., Kalb, J. M., Wolfner, M. F., Partridge, L. 1995. “Cost of Mating in Drosophila melanogaster Females Is Mediated by Male Accessory Gland Products”. Nature 373:241–44, https://doi.org/10.1038/373241a0.

22 Piper, M. D. W., et al. 2017. “Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan”. Cell Metabolism 25:610–21, https://doi.org/10.1016/j.cmet.2017.02.005.

23 Klass, M. R. 1983. “A Method for the Isolation of Longevity Mutants in the Nematode Caenorhabditis elegans and Initial Results”. Mechanisms of Ageing and Development 22:279–86, https://doi.org/10.1016/0047–6374 (83) 90082–9.

24 Friedman, D. B., Johnson, T. E. 1988. “A Mutation in the age-1 Gene in Caenorhabditis elegans Lengthens Life and Reduces Hermaphrodite Fertility”. Genetics 118:75–86.

25 Morris, J. Z., Tissenbaum, H. A., Ruvkun, G. 1996. “A Phosphatidylinositol-3-OH Kinase Family Member Regulating Longevity and Diapause in Caenorhabditis elegans”. Nature 382:536–39.

26 Kenyon, C., Chang, J., Gensch, E., Rudner, A., Tabtiang, R. 1993. “A C. elegans Mutant that Lives Twice as Long as Wild Type”. Nature 366:461–64.

27 Kimura, K. D., Tissenbaum, H. A., Liu, Y., Ruvkun, G. 1997. “daf-2, an Insulin Receptor-like Gene that Regulates Longevity and Diapause in Caenorhabditis elegans”. Science 277:942–46.

28 Ogg, S., et al. 1997. “The Fork Head Transcription Factor DAF-16 Transduces Insulin-like Metabolic and Longevity Signals in C. elegans”. Nature 389:994–99; Lin, K., Dorman, J. B., Rodan, A., Kenyon, C. 1997. “daf-16: An HNF-3/Forkhead Family Member that Can Function to Double the Life-Span of Caenorhabditis elegans”. Science 278:1319–22.