Аннотация
This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, finechemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring keycompounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates areidentified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, andacademicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent,and solvent selection; optimising catalytic reactions; chiral syntheses; and "e;green chemistry."e; "e;Practical Process Research and Development"e; will be a valuable resource for researchers, managers, and graduate students.* Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "e;small molecules"e;* Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more* Includes over 100 tips for rapid process development* Presents guidelines for implementing and troubleshooting processes
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