Как мы стареем

15 Hughes, G. M., Leech, J., Puechmaille, S. J., Lopez, J. V., Teeling, E. C. 2018. “Is There a Link between Aging and Microbiome Diversity in Exceptional Mammalian Longevity?” PeerJ 6: e4174, https://doi.org/10.7717/peerj.4174.

16 Anderson et al. 2018.

17 Wu, L., et al. 2019. “A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians”. mSystems 4: e00325–19, https://doi.org/10.1128/mSystems.00325–19.

18 Biagi, E., et al. 2010. “Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians”. PLOS One 5: e10667, https://doi.org/10.1371/journal.pone.0010667.

19 Luan, Z., et al. 2020. “Metagenomics Study Reveals Changes in Gut Microbiota in Centenarians: A Cohort Study of Hainan Centenarians”. Frontiers in Microbiology 11:1474, https://doi.org/10.3389/fmicb.2020.01474.

20 Ridaura, V. K., et al. 2013. “Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice”. Science 341:1241214, https://doi.org/10.1126/science.1241214.

21 D’Amato, A., et al. 2020. “Faecal Microbiota Transplant from Aged Donor Mice Affects Spatial Learning and Memory via Modulating Hippocampal Synaptic Plasticity- and Neurotransmission-Related Proteins in Young Recipients”. Microbiome 8:140, https://doi.org/10.1186/s40168-020-00914-w.

22 Kundu, P., et al. 2019. “Neurogenesis and Prolongevity Signaling in Young Germ-Free Mice Transplanted with the Gut Microbiota of Old Mice”. Science Translational Medicine 11: eaau4760, https://doi.org/10.1126/scitranslmed.aau4760.

23 Sugimoto, Y., et al. 2019. “A Metagenomic Strategy for Harnessing the Chemical Repertoire of the Human Microbiome”. Science 366: eaax9176, https://doi.org/10.1126/science.aax9176.

24 Bárcena et al. 2019.

25 Smith, P., et al. 2017. “Regulation of Life Span by the Gut Microbiota in the Short-Lived African Turquoise Killifish”. eLife 6: e27014, https://doi.org/10.7554/eLife.27014.

26 Boehme, M., et al. 2021. “Microbiota from Young Mice Counteracts Selective Age-Associated Behavioral Deficits”. Nature Aging 1:666–76, https://doi.org/10.1038/s43587-021-00093-9.

27 Bonaz, B., Bazin, T., Pellissier, S. 2018. “The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis”. Frontiers in Neuroscience 12:49, https://doi.org/10.3389/fnins.2018.00049; Cryan, J. F., et al. 2019. “The Microbiota-Gut-Brain Axis”. Physiological Reviews 99:1877–2013, https://doi.org/10.1152/physrev.00018.2018.

28 Tran, T. T. T., et al. 2019. “APOE Genotype Influences the Gut Microbiome Structure and Function in Humans and Mice: Relevance for Alzheimer’s Disease Pathophysiology”. FASEB Journal 33:8221–31, https://doi.org/10.1096/fj.201900071R.

29 Braak, H., Rüb, U., Gai, W. P., Del Tredici, K. 2003. “Idiopathic Parkinson’s Disease: Possible Routes by which Vulnerable Neuronal Types May Be Subject to Neuroinvasion by an Unknown Pathogen”. Journal of Neural Transmission 110:517–36, https://doi.org/10.1007/s00702-002-0808-2.

30 Sampson, T. R., et al. 2016. “Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease”. Cell 167:1469–80.e12, https://doi.org/10.1016/j.cell.2016.11.018.

31 Yap et al. 2021.

32 Pellanda, P., Ghosh, T. S., O’Toole, P. W. 2021. “Understanding the Impact of Age-Related Changes in the Gut Microbiome on Chronic Diseases and the Prospect of Elderly-Specific Dietary Interventions”. Current Opinion in Biotechnology 70:48–55, https://doi.org/10.1016/j.copbio.2020.11.001.

33 Van de Wouw, M., et al. 2021. “Kefir Ameliorates Specific Microbiota-Gut-Brain Axis Impairments in a Mouse Model Relevant to Autism Spectrum Disorder”. Brain, Behavior, and Immunity 97:119–34, https://doi.org/10.1016/j.bbi.2021.07.004.

34 Buettner, D., Skemp, S. 2016. “Blue Zones: Lessons From the World’s Longest Lived”. American Journal of Lifestyle Medicine 10:318–21, https://doi.org/10.1177/155 982761 663 7066.

35 Pellanda, Ghosh, O’Toole 2021.

36 Ghosh, T. S., et al. 2020. “Mediterranean Diet Intervention Alters the Gut Microbiome in Older People Reducing Frailty and Improving Health Status: The NU-AGE 1-Year Dietary Intervention across Five European Countries”. Gut 69:1218–28, https://doi.org/10.1136/gutjnl-2019–319654.

37 Rangan, P., et al. 2019. “Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology”. Cell Reports 26:2704–19.e6, https://doi.org/10.1016/j.celrep.2019.02.019.

Глaвa 17. Тaблетки долголетия

1 Isaak, A. 2020. “The Ultra-rich Are Investing in Companies Trying to Reverse Aging. Is It Going to Work?” CNBC, February 23, 2020, https://www.cnbc.com/2020/02/19/the-ultra-rich-are-investing-in-companies-trying-to-reverse-aging.html.

2 Nanalyze. 2019. “The Top 10 Companies Working to Increase Longevity”. August 17, 2019, https://www.nanalyze.com/2019/08/top-10-companies-longevity/.

3 Zimmerma

4 Ristow, M., et al. 2009. “Antioxidants Prevent Health-Promoting Effects of Physical Exercise in Humans”. Proceedings of the National Academy of Sciences of the USA 106:8665–70, https://doi.org/10.1073/pnas.0903485106.

5 Cross, R. 2019. “Autophagy: Drugging the Yin and Yang of the Cell”. C&EN, June 2, 2019, https://cen.acs.org/business/start-ups/Autophagy-Drugging-yin-yang-cell/97/i22.

6 Rabouw, H. H., et al. 2019. “Small Molecule ISRIB Suppresses the Integrated Stress Response within a Defined Window of Activation”. Proceedings of the National Academy of Sciences of the USA 116:2097–2102, https://doi.org/10.1073/pnas.1815767116.

7 Chou, A., et al. 2017. “Inhibition of the Integrated Stress Response Reverses Cognitive Deficits after Traumatic Brain Injury”. Proceedings of the National Academy of Sciences of the USA 114: E6420–26, https://doi.org/10.1073/pnas.1707661114; Krukowski, K., et al. 2020. “Small Molecule Cognitive Enhancer Reverses Age-Related Memory Decline in Mice”. eLife 9: e62048, https://doi.org/10.7554/eLife.62048.

8 Krukowski et al. 2020.

9 Onken, B., et al. 2020. “Metformin Treatment of Diverse Caenorhabditis Species Reveals the Importance of Genetic Background in Longevity and Healthspan Extension Outcomes”. Aging Cell 21: e13488, https://doi.org/10.1111/acel.13488; Seliger, S. L., et al. 2020. “Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial”. Kidney360 1:1363–72, https://doi.org/10.34067/KID.0004002020.

10 Aliper, A., et al. 2017. “Towards Natural Mimetics of Metformin and Rapamycin”. Aging (Albany NY) 9:2245–68, https://doi.org/10.18632/aging.101319.

11 US National Library of Medicine. 2022. “Participatory Evaluation (of) Aging (with) Rapamycin (for) Longevity Study (PEARL)”. Clinical Trials.gov, id: NCT04488601, последнее обновление 4 октября 2022, https://clinicaltrials.gov/ct2/show/NCT04488601.

12 Curran, S. P., Ruvkun, G. 2007. “Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability”. PLOS Genetics 3: e56, https://doi.org/10.1371/journal.pgen.0030056; Tacutu, R., et al. 2012. “Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks”. PLOS One 7: e48282, https://doi.org/10.1371/journal.pone.0048282.

13 Harrison, D. E., et al. 2009. “Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice”. Nature 460:392–95, https://doi.org/10.1038/nature08221.

14 Dillin, A., Crawford, D. K., Kenyon, C. 2002. “Timing Requirements for Insulin/IGF-1 Signaling in C. elegans”. Science 298:830–34.

15 Venz, R., Pekec, T., Katic, I., Ciosk, R., Ewald, C. Y. 2021. “End-of-Life Targeted Auxin-Mediated Degradation of DAF-2 Insulin/IGF-1 Receptor Promotes Longevity Free from Growth-Related Pathologies”. eLife 10: e71335, https://doi.org/10.7554/eLife.71335.

16 Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C., Koutsifeli, P., Buckels, E. J., et al. 2023. “Dietary Supplementation of Clinically Utilized PI3K p110α Inhibitor Extends the Lifespan of Male and Female Mice”. Nature Aging, https://doi.org/10.1038/s43587-022-00349-y.

17 Fan, W., Evans, R. M. 2017. “Exercise Mimetics: Impact on Health and Performance”. Cell Metabolism 25:242–47, https://doi.org/10.1016/j.cmet.2016.10.022.

18 Guerrieri, D., Moon, H. Y., van Praag, H. 2017. “Exercise in a Pill: The Latest on Exercise-Mimetics”. Brain Plasticity 2:153–69, https://doi.org/10.3233/BPL-160043.

19 Merrill, G. F., Kurth, E. J., Hardie, D. G., Winder, W. W. 1997. “AICA Riboside Increases AMP-Activated Protein Kinase, Fatty Acid Oxidation, and Glucose Uptake in Rat Muscle”. American Journal of Physiology 273: E1107–12, https://doi.org/10.1152/ajpendo.1997.273.6. E1107; Asby, D. J., et al. 2015. “AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization”. Chemistry and Biology 22:838–48, https://doi.org/10.1016/j.chembiol.2015.06.008.

20 Macmichael, S. 2012. “Spanish Police Arrest Ten as They Break up ‘Next Generation Superdrug’ Doping Ring in Operacion Skype”. Road.cc, March 20, 2012, https://road.cc/content/news/55184-spanish-police-arrest-ten-they-break-next-generation-superdrug-doping-ring.

21 Asby et al. 2015; Associated Press, 2014. “Doping Probe Launched into Russian Walkers”. ESPN, July 11, 2014. http://www.espn.com/espn/wire?section =trackandfield&id  =112  01932; Canadian Cycling Magazine, 2012, “New Doping Scandal Hits Cycling and Athletics”. March 22, 2012, https://cyclingmagazine.ca/sections/news/new-doping-scandal-hits-cycling-and-athletics/.

22 Ryu, D., et al. 2016. “Urolithin A Induces Mitophagy and Prolongs Lifespan in C. elegans and Increases Muscle Function in Rodents”. Nature Medicine 22:879–88, https://doi.org/10.1038/nm.4132.

23 Germain, D. J., Leavey, D. C., Van Hout, P. M. C., McVeigh, P. J. 2021. “2,4 Dinitrophenol: It’s Not Just for Men”. International Journal of Drug Policy 95:102987, https://doi.org/10.1016/j.drugpo.2020.102987; Petróczi, A., et al. 2015. “Russian Roulette with Unlicensed Fat-Burner Drug 2,4-dinitrophenol (DNP): Evidence from a Multidisciplinary Study of the Internet, Bodybuilding Supplements and DNP Users”. Substance Abuse Treatment, Prevention, and Policy 10:39, https://doi.org/10.1186/s13011-015-0034-1.

24 Hall, S. S. 2004. “Kenyon’s Ageless Quest”. Smithsonian Magazine, March 2004, https://www.smithsonianmag.com/science-nature/kenyons-ageless-quest-103525532/; Staats, S., et al. 2018. “Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster”. International Journal of Molecular Sciences 19:223, https://doi.org/10.3390/ijms19010223.