Как мы стареем

28 Moore, L. D., Le, T., Fan, G. 2013. “DNA Methylation and Its Basic Function”. Neuropsychopharmacology 38:23–38, https://doi.org/10.1038/npp.2012.112.

29 Herb, B. R., et al. 2012. “Reversible Switching between Epigenetic States in Honeybee Behavioral Subcastes”. Nature Neuroscience 15:1371–73, https://doi.org/10.1038/

30 Horvath, S. 2013. “DNA Methylation Age of Human Tissues and Cell Types”. Genome Biology 14: R115, https://doi.org/10.1186/gb-2013-14-10-r115.

31 Ha

32 Liu, Z., et al. 2020. “Under lying Features of Epigenetic Aging Clocks In Vivo and In Vitro”. Aging Cell 19: e13229, https://doi.org/10.1111/acel.13229; Levine, M. E. 2020. “Assessment of Epigenetic Clocks as Biomarkers of Aging in Basic and Population Research”. Journals of gerontology, Series A, Biological Sciences and Medical Sciences 75:463–65, https://doi.org/10.1093/gerona/glaa021; Schmitz, L. L., et al. 2021. “The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-ethnic Study of Atherosclerosis and the Health and Retirement Study”. Epigenetics 17:589–611, опубликовaно в электронном виде до выходa в печaть 6 июля 2021 г., https://doi.org/10.1080/15592294.2021.1939479.

33 Levine, M. E., et al. 2016. “Menopause Accelerates Biological Aging”. Proceedings of the National Academy of Sciences of the USA 113:9327–32, https://doi.org/10.1073/pnas.1604558113.

34 Buckley, M. T., et al. 2022. “Cell Type-Specific Aging Clocks to Quantify Aging and Rejuvenation in Regenerative Regions of the Brain”. bioRxiv, 2022.01.10.475747, https://doi.org/10.1101/2022.01.10.475747.

35 Olins, D. E., Olins, A. L. 1978. “Nucleosomes: The Structural Quantum in Chromosomes”. American Scientist 66:704–11.

36 Farrelly, L. A., et al. 2019. “Histone Serotonylation Is a Permissive Modification that Enhances TFIID Binding to H3K4me3”. Nature 567:535–39, https://doi.org/10.1038/s41586-019-1024-7.

37 Ma, Z., et al. 2018. “Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity in Drosophila”. eLife 7: e35368, https://doi.org/10.7554/eLife.35368.

38 Cheung, P., et al. 2018. “Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging”. Cell 173:1385–97.e14, https://doi.org/10.1016/j.cell.2018.03.079.

39 Benayoun, B. A., et al. 2019. “Remodeling of Epigenome and Transcriptome Landscapes with Aging in Mice Reveals Widespread Induction of Inflammatory Responses”. Genome Research 29:697–709, https://doi.org/10.1101/gr.240093.118.

40 Greer, E. L., et al. 2010. “Members of the H3K4 Trimethylation Complex Regulate Lifespan in a Germline-Dependent Ma

41 Maures, T. J., Greer, E. L., Hauswirth, A. G., Brunet, A. 2011. “The H3K27 Demethylase UTX-1 Regulates C. elegans Lifespan in a Germline-Independent, Insulin-Dependent Ma

42 Guillermo, A. R. R., et al. 2021. “H3K27 Modifiers Regulate Lifespan in C. elegans in a Context-Dependent Ma

43 Greer, E. L., et al. 2011. “Transgenerational Epigenetic Inheritance of Longevity in Caenorhabditis elegans”. Nature 479:365–71, https://doi.org/10.1038/nature10572.

44 Han, S., et al. 2017. “Mono-unsaturated Fatty Acids Link H3K4me3 Modifiers to C. elegans Lifespan”. Nature 544:185–90, https://doi.org/10.1038/nature21686.

45 Lee, T. W., David, H. S., Engstrom, A. K., Carpenter, B. S., Katz, D. J. 2019. “Repressive H3K9me2 Protects Lifespan against the Transgenerational Burden of COMPASS Activity in C. elegans”. eLife 8: e48498, https://doi.org/10.7554/eLife.48498.

46 Liu, Z. C., Ambros, V. 1989. “Heterochronic Genes Control the Stage-Specific Initiation and Expression of the Dauer Larva Developmental Program in Caenorhabditis elegans”. Genes and Development 3:2039–49, https://doi.org/10.1101/gad.3.12b.2039; Lee, R. C., Ambros, V. 2001. “An Extensive Class of Small RNAs in Caenorhabditis elegans”. Science 294:862–64, https://doi.org/10.1126/science.1065329.

47 Zia, A., Farkhondeh, T., Sahebdel, F., Pourbagher-Shahri, A. M., Samarghandian, S. 2021. “Key miRNAs in Modulating Aging and Longevity: A Focus on Signaling Pathways and Cellular Targets”. Current Molecular Pharmacology 15:736–62, https://doi.org/10.2174/1874467214666210917141541; Kinser, H. E., Pincus, Z. 2020. “MicroRNAs as Modulators of Longevity and the Aging Process”. Human Genetics 139:291–308, https://doi.org/10.1007/s00439-019-02046-0; Boehm, M., Slack, F. 2005. “A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans”. Science 310:1954–57, https://doi.org/10.1126/science.1115596.

48 Zia et al. 2021; Kinser, Pincus 2020; Boehm, Slack 2005.

49 Baugh, L. R., Hu, P. J. 2020. “Starvation Responses throughout the Caenorhabditis elegans Life Cycle”. Genetics 216:837–78, https://doi.org/10.1534/genetics.120.303565.

50 Angelo, G., Van Gilst, M. R. 2009. “Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C. elegans”. Science 326:954–58, https://doi.org/10.1126/science.1178343.

51 Jobson, M. A., et al. 2011. “Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans”. Genetics 201:201–12, https://doi.org/10.1534/genetics.115.178699; Greer et al. 2011.

52 Rechavi, O., et al. 2014. “Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans”. Cell 158:277–87, https://doi.org/10.1016/j.cell.2014.06.020.

53 Zhang, Y., Lu, H., Bargma

54 Jin, X., Pokala, N., Bargma

55 Moore, R. S., Kaletsky, R., Murphy, C. T. 2019. “Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance”. Cell 177:1827–41.e12, https://doi.org/10.1016/j.cell.2019.05.024.

56 Moore, Kaletsky, Murphy 2019.

57 Kaletsky, R., et al. 2020. “C. elegans ‘Reads’ Bacterial Non-coding RNAs to Learn Pathogenic Avoidance”. bioRxiv, 2020.01.26.920322, https://doi.org/10.1101/2020.01.26.920322.

58 Kaletsky, R., et al. 2020. “C. elegans Interprets Bacterial Non-coding RNAs to Learn Pathogenic Avoidance”. Nature 586:445–51, https://doi.org/10.1038/s41586-020-2699-5.

59 Moore, R. S., et al. 2021. “The Role of the Cer1 Transposon in Horizontal Transfer of Transgenerational Memory”. Cell 184:4697–4712.e18, https://doi.org/10.1016/j.cell.2021.07.022.

60 Lim, A. I., et al. 2021. “Prenatal Maternal Infection Promotes Tissue-Specific Immunity and Inflammation in Offspring”. Science 373: eabf3002, doi: https://doi.org/10.1126/science.abf3002.

Глaвa 16. Сaмочувствие кишечникa

1 Bana, B., Cabreiro, F. 2019. “The Microbiome and Aging”. A

2 Yap, C. X., et al. 2021. “Autism-Related Dietary Preferences Mediate Autism-Gut Microbiome Associations”. Cell 184:5916–31.e17, https://doi.org/10.1016/j.cell.2021.10.015.

3 Bárcena, C., et al. 2019. “Healthspan and Lifespan Extension by Fecal Microbiota Transplantation into Progeroid Mice”. Nature Medicine 25:1234–42, https://doi.org/10.1038/s41591-019-0504-5.

4 Samuel, B. S., Rowedder, H., Braendle, C., Felix, M. A., Ruvkun, G. 2016. “Caenorhabditis elegans Responses to Bacteria from Its Natural Habitats”. Proceedings of the National Academy of Sciences of the USA 113: E3941–49, https://doi.org/10.1073/pnas.1607183113.

5 Rera, M., Clark, R. I., Walker, D. W. 2012. “Intestinal Barrier Dysfunction Links Metabolic and Inflammatory Markers of Aging to Death in Drosophila”. Proceedings of the National Academy of Sciences of the USA 109:21528–33, https://doi.org/10.1073/pnas.1215849110.

6 Clark, R. I., et al. 2015. “Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality”. Cell Reports 12:1656–67, https://doi.org/10.1016/j.celrep.2015.08.004.

7 Anderson, K. E., et al. 2018. “The Queen’s Gut Refines with Age: Longevity Phenotypes in a Social Insect Model”. Microbiome 6:108, https://doi.org/10.1186/s40168-018-0489-1; Kunugi, H., Mohammed Ali, A. 2019. “Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans”. International Journal of Molecular Sciences 20:4662, https://doi.org/10.3390/ijms20194662; Liu, P., et al. 2021. “Overwintering Honeybees Maintained Dynamic and Stable Intestinal Bacteria”. Scientific Reports 11:22233, https://doi.org/10.1038/s41598-021-01204-7.

8 Pascale, A., et al. 2018. “Microbiota and Metabolic Diseases”. Endocrine 61:357–71, https://doi.org/10.1007/s12020-018-1605-5.

9 Brice, K. L., et al. 2019. “The Koala (Phascolarctos cinereus) Faecal Microbiome Differs with Diet in a Wild Population”. PeerJ 7: e6534, https://doi.org/10.7717/peerj.6534.

10 Rothschild, D., et al. 2018. “Environment Dominates over Host Genetics in Shaping Human Gut Microbiota”. Nature 555:210–15, https://doi.org/10.1038/nature25973.

11 Holscher, H. D. 2017. “Dietary Fiber and Prebiotics and the Gastrointestinal Microbiota”. Gut Microbes 8:172–84, https://doi.org/10.1080/19490976.2017.1290756; Suez, J., et al. 2014. “Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota”. Nature 514:181–86, https://doi.org/10.1038/nature13793.

12 Reveles, K. R., Patel, S., Forney, L., Ross, C. N. 2019. “Age-Related Changes in the Marmoset Gut Microbiome”. American Journal of Primatology 81: e22960, https://doi.org/10.1002/ajp.22960; Scott, K. A., et al. 2017. “Revisiting Metchnikoff: Age-Related Alterations in Microbiota-Gut-Brain Axis in the Mouse”. Brain, Behavior, and Immunity 65:20–32, https://doi.org/10.1016/j.bbi.2017.02.004; Langille, M. G., et al. 2014. “Microbial Shifts in the Aging Mouse Gut”. Microbiome 2:50, https://doi.org/10.1186/s40168-014-0050-9.

13 Bárcena et al. 2019.

14 Luan, Z., et al. 2020. “Metagenomics Study Reveals Changes in Gut Microbiota in Centenarians: A Cohort Study of Hainan Centenarians”. Frontiers in Microbiology 11:1474, https://doi.org/10.3389/fmicb.2020.01474.