Аннотация
Hormonal Proteins and Peptides: -Endorphin, Volume X focuses on the chemistry, biology, and clinical investigations of opioid peptides. This book discusses the chemical approach in isolating a chemical entity from its natural source and investigates its biological activity after it has been determined to be a pure substance. Organized into nine chapters, this volume starts with an overview of the structure-activity relationship of -endorphin (-EP) by synthetic approach. This text then explores the proteinases involved in the generation of opioid peptides, including -EP from -lipotropin (-LPH). Other chapters review the biosynthesis of -EP and consider in detail the opiate receptor. This book discusses as well the anatomy of -EP-containing structures in pituitary and brain. The final chapter presents a discussion on the historical aspects of opiate-peptide discoveries, particularly in the field of narcotic antagonists. This book is a valuable resource for chemists, biologists, endocrinologists, physicians, and neurobiologists.
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