Как мы стареем

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24 Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M., Haynes, C. M. 2012. “Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation”. Science 337:587–90, https://doi.org/10.1126/science.1223560.

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26 Merkwirth et al. 2016.

27 Zhang, Q., et al. 2021. “The Memory of Neuronal Mitochondrial Stress Is Inherited Transgenerationally via Elevated Mitochondrial DNA Levels”. Nature Cell Biology 23:870–80, https://doi.org/10.1038/s41556-021-00724-8.

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29 Хоaкин Нaвaхaс Аседо (MadScientist, @MadS100tist), 2021. “Почему мы нaзывaем это ответом нa несвернутый белок, a не пaникой в ЭР”. Twitter, 18 ноября 2021, 18:53.

30 Goudeau, J., Samaddar, M., Bohnert, K. A., Kenyon, C. 2020. “Addendum: A Lysosomal Switch Triggers Proteostasis Renewal in the Immortal C. elegans Germ Lineage”. Nature 580: E5, https://doi.org/10.1038/s41586-020-2108-0.

31 Zhang, Q., et al. 2018. “The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling”. Cell 174:870–83.e17, https://doi.org/10.1016/j.cell.2018.06.029.

32 Kaushik, S., et al. 2021. “Autophagy and the Hallmarks of Aging”. Ageing Research Reviews 72:101468, https://doi.org/10.1016/j.arr.2021.101468; Nieto-Torres, J. L., Hansen, M. 2021. “Macroautophagy and Aging: The Impact of Cellular Recycling on Health and Longevity”. Molecular Aspects of Medicine 82:101020, https://doi.org/10.1016/j.mam.2021.101020.

33 Aman, Y., et al. 2021. “Autophagy in Healthy Aging and Disease”. Nature Aging 1:634–50, https://doi.org/10.1038/s43587-021-00098-4.

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35 Aman et al. 2021.

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37 Rangaraju, S., et al. 2015. “Suppression of Transcriptional Drift Extends C. elegans Life span by Postponing the Onset of Mortality”. eLife 4: e08833, https://doi.org/10.7554/eLife.08833.

38 Seo, M., et al. 2015. “RNA Helicase HEL-1 Promotes Longevity by Specifically Activating DAF-16/FOXO Transcription Factor Signaling in Caenorhabditis elegans”. Proceedings of the National Academy of Sciences of the USA 112: E4246–55, https://doi.org/10.1073/pnas.1505451112.

39 Son, H. G., et al. 2017. “RNA Surveillance via Nonsense-Mediated mRNA Decay Is Crucial for Longevity in daf-2/Insulin/IGF-1 Mutant C. elegans”. Nature Communications 8:14749, https://doi.org/10.1038/ncomms14749.

40 Kuroyanagi, H., Ohno, G., Sakane, H., Maruoka, H., Hagiwara, M. 2010. “Visualization and Genetic Analysis of Alternative Splicing Regulation In Vivo Using Fluorescence Reporters in Transgenic Caenorhabditis elegans”. Nature Protocols 5:1495–1517, https://doi.org/10.1038/nprot.2010.107; Heintz, C., et al. 2017. “Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans”. Nature 541:102–6, https://doi.org/10.1038/nature20789.

41 Kew, C., et al. 2020. “Evolutionarily Conserved Regulation of Immunity by the Splicing Factor RNP-6/PUF60”. eLife 9: e57591, https://doi.org/10.7554/eLife.57591.

42 Rhoads, T. W., et al. 2018. “Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys”. Cell Metabolism 27:677–88.e5, https://doi.org/10.1016/j.cmet.2018.01.014.

43 Ibanez-Ventoso, C., et al. 2006. “Modulated MicroRNA Expression during Adult Lifespan in Caenorhabditis elegans”. Aging Cell 5:235–46, https://doi.org/10.1111/j.1474–9726.2006.00210.x; Inukai, S., Pincus, Z., de Lencastre, A., Slack, F. J. 2018. “A MicroRNA Feedback Loop Regulates Global MicroRNA Abundance during Aging”. RNA 24:159–72, https://doi.org/10.1261/rna.062190.117; Smith-Vikos, T., et al. 2014. “MicroRNAs Mediate Dietary-Restriction-Induced Longevity through PHA-4/FOXA and SKN-1/Nrf Transcription Factors”. Current Biology 24:2238–46, https://doi.org/10.1016/j.cub.2014.08.013; Inukai, S., de Lencastre, A., Turner, M., Slack, F. 2012. “Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain”. PLOS One 7: e40028, https://doi.org/10.1371/journal.pone.0040028; De Lencastre, A., et al. 2010. “MicroRNAs Both Promote and Antagonize Longevity in C. elegans”. Current Biology 20:2159–68, https://doi.org/10.1016/j.cub.2010.11.015; Pincus, Z., Smith-Vikos, T., Slack, F. J. 2011. “MicroRNA Predictors of Longevity in Caenorhabditis elegans”. PLOS Genetics 7: e1002306, https://doi.org/10.1371/journal.pgen.1002306.

44 Pincus, Smith-Vikos, Slack 2011; Ruediger, C., Karimzadegan, S., Lin, S., Shapira, M. 2021. “miR-71 Mediates Age-Dependent Opposing Contributions of the Stress-Activated Kinase KGB-1 in Caenorhabditis elegans”. Genetics 218: iya049, https://doi.org/10.1093/genetics/iyab049; Hsieh, Y. W., Chang, C., Chuang, C. F. 2012. “The MicroRNA mir-71 Inhibits Calcium Signaling by Targeting the TIR-1/Sarm1 Adaptor Protein to Control Stochastic L/R Neuronal Asymmetry in C. elegans”. PLOS Genetics 8: e1002864, https://doi.org/10.1371/journal.pgen.1002864; Boulias, K., Horvitz, H. R., 2012. “The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO”. Cell Metabolism 15:439–50, https://doi.org/10.1016/j.cmet.2012.02.014; Boehm, M., Slack, F. 2005. “A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans”. Science 310:1954–57, https://doi.org/10.1126/science.1115596.

45 Finger, F., et al. 2019. “Olfaction Regulates Organismal Proteostasis and Longevity via MicroRNA-Dependent Signaling”. Nature Metabolism 1:350–59, https://doi.org/10.1038/s42255-019-0033-z.

46 Vesely, C., Jantsch, M. F. 2021. “An I for an A: Dynamic Regulation of Adenosine Deamination-Mediated RNA Editing”. Genes 12:1026, https://doi.org/10.3390/genes12071026.

47 Vesely, Jantsch 2021.

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49 Oguro, R., et al. 2012. “A Single Nucleotide Polymorphism of the Adenosine Deaminase, RNA-Specific Gene Is Associated with the Serum Triglyceride Level, Abdominal Circumference, and Serum Adiponectin Concentration”. Experimental Gerontology 47:183–87, https://doi.org/10.1016/j.exger.2011.12.004.

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52 Memczak, S., et al. 2013. “Circular RNAs Are a Large Class of Animal RNAs with Regulatory Potency”. Nature 495:333–38, https://doi.org/10.1038/nature11928.

Глaвa 9. Топливо для долгой жизни

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7 Schriner, S. E., et al. 2005. “Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria”. Science 308:1909–11, https://doi.org/10.1126/science.1106653.

8 Yen, C. A., Curran, S. P. 2021. “Incomplete Proline Catabolism Drives Premature Sperm Aging”. Aging Cell 20: e13308, https://doi.org/10.1111/acel.13308.

9 Sun, Y., et al. 2020. “Lysosome Activity Is Modulated by Multiple Longevity Pathways and Is Important for Lifespan Extension in C. elegans”. eLife 9: e55745, https://doi.org/10.7554/eLife.55745.

10 Salmon, A. B., et al. 2009. “The Long Lifespan of Two Bat Species Is Correlated with Resistance to Protein Oxidation and Enhanced Protein Homeostasis”. FASEB Journal 23:2317–26, https://doi.org/10.1096/fj.08–122523.

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