Как мы стареем

13 Lamb, M. J. 1968. “Temperature and Lifespan in Drosophila”. Nature 220:808–9, https://doi.org/10.1038/220808a0; Aigaki, T., Ohba, S. 1984. “Effect of Mating Status on Drosophila virilis Lifespan”. Experimental Gerontology 19:267–78, https://doi.org/10.1016/0531–5565 (84) 90022–6; Chapman, T., Hutchings, J., Partridge, L. 1993. “No Reduction in the Cost of Mating for Drosophila melanogaster Females Mating with Spermless Males”. Proceedings of the Royal Society B: Biological Sciences 253:211–17, https://doi.org/10.1098/rspb.1993.0105; Chapman, T., Herndon, L. A., Heifetz, Y., Partridge, L., Wolfner, M. F. 2001. “The Acp26Aa Seminal Fluid Protein Is a Modulator of Early Egg Hatchability in Drosophila melanogaster”. Proceedings of the Royal Society B: Biological Sciences 268:1647–54, https://doi.org/10.1098/rspb.2001.1684; Rose, M. R. 1989. “Genetics of Increased Lifespan in Drosophila”. Bioessays 11:132–35, https://doi.org/10.1002/bies.950110505.

14 Clancy et al. 2001.

15 Tatar et al. 2001.

16 Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M., Tatar, M. 2004. “Drosophila dFOXO Controls Lifespan and Regulates Insulin Signalling in Brain and Fat Body”. Nature 429:562–66.

17 Libina, N., Berman, J. R., Kenyon, C. 2003. “Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan”. Cell 115:489–502.

18 Broughton, S. J., et al. 2010. “DILP-Producing Median Neurosecretory Cells in the Drosophila Brain Mediate the Response of Lifespan to Nutrition”. Aging Cell 9:336–46, https://doi.org/10.1111/j.1474–9726.2010.00558.x.

19 Holzenberger, M., et al. 2003. “IGF-1 Receptor Regulates Lifespan and Resistance to Oxidative Stress in Mice”. Nature 421:182–87; Hsieh, C. C., DeFord, J. H., Flurkey, K., Harrison, D. E., Papaconstantinou, J. 2002. “Effects of the Pit1 Mutation on the Insulin Signaling Pathway: Implications on the Longevity of the Long-Lived Snell Dwarf Mouse”. Mechanisms of Ageing and Development 123:1245–55; Hsieh, C. C., DeFord, J. H., Flurkey, K., Harrison, D. E., Papaconstantinou, J. 2002. “Implications for the Insulin Signaling Pathway in Snell Dwarf Mouse Longevity: A Similarity with the C. elegans Longevity Paradigm”. Mechanisms of Ageing and Development 123:1229–44.

20 Holzenberger et al. 2003.

21 Bluher, M., Kahn, B. B., Kahn, C. R. 2003. “Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue”. Science 299:572–74.

22 Burks, D. J., et al. 2000. “IRS-2 Pathways Integrate Female Reproduction and Energy Homeostasis”. Nature 407:377–82, https://doi.org/10.1038/35030105.

23 Suh, Y., et al. 2008. “Functionally Significant Insulin-Like Growth Factor I Receptor Mutations in Centenarians”. Proceedings of the National Academy of Sciences of the USA 105:3438–42.

24 Hedges, C. P., Shetty, B., Broome, S. C., MacRae, C., Koutsifeli, P., Buckels, E. J., et al. 2023. “Dietary Supplementation of Clinically Utilized PI3K p110α Inhibitor Extends the Lifespan of Male and Female Mice”. Nature Aging, https://doi.org/10.1038/s43587-022-0349-y.

25 Murphy, C. T., et al. 2003. “Genes that Act Downstream of DAF-16 to Influence the Lifespan of Caenorhabditis elegans”. Nature 424:277–83.

26 Tepper, R. G., Ashraf, J., Kaletsky, R., Kleema

27 Furuyama, T., Nakazawa, T., Nakano, I., Mori, N. 2000. “Identification of the Differential Distribution Patterns of mRNAs and Consensus Binding Sequences for Mouse DAF-16 Homologues”. Biochemical Journal 349:629–34.

28 Lee, S. S., Ke

29 McElwee, J. J., Schuster, E., Blanc, E., Thomas, J. H., Gems, D. 2004. “Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-Lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance”. Journal of Biological Chemistry 279:44533–43.

30 Tepper et al. 2013. Ген pqm-1 был выявлен при скрининге чувствительности к пaрaквaту в середине 1990-х годов, но после этого его больше не изучaли.

31 Hsu, A. L., Murphy, C. T., Kenyon, C. 2003. “Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor”. Science 300:1142–45; Tullet, J. M., et al. 2008. “Direct Inhibition of the Longevity-Promoting Fact or SKN-1 by Insulin-like Signaling in C. elegans”. Cell 132:1025–38, https://doi.org/10.1016/j.cell.2008.01.030; Lapierre, L. R., et al. 2013. “The TFEB Orthologue HLH-30 Regulates Autophagy and Modulates Longevity in Caenorhabditis elegans”. Nature Communications 4:2267, https://doi.org/10.1038/ncomms3267; Riedel, C. G., et al. 2013. “DAF-16 Employs the Chromatin Remodeller SWI/SNF to Promote Stress Resistance and Longevity”. Nature Cell Biology 15:491–501, https://doi.org/10.1038/ncb2720.

32 Soukas, A. A., Kane, E. A., Carr, C. E., Melo, J. A., Ruvkun, G. 2009. “Rictor/TORC2 Regulates Fat Metabolism, Feeding, Growth, and Life Span in Caenorhabditis elegans”. Genes and Development 23:496–511, https://doi.org/10.11 01/gad.1775409; Oh, S. W., et al. 2005. “JNK Regulates Lifespan in Caenorhabditis elegans by Modulating Nuclear Translocation of Forkhead Transcription Factor/DAF-16”. Proceedings of the National Academy of Sciences of the USA 102:4494–99.

33 Berdichevsky, A., Viswanathan, M., Horvitz, H. R., Guarente, L. 2006. “C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span”. Cell 125:1165–77.

34 Tepper et al. 2013.

35 Perez, M. F., Francesconi, M., Hidalgo-Carcedo, C., Lehner, B. 2017. “Maternal Age Generates Phenotypic Variation in Caenorhabditis elegans”. Nature 552:106–9, https://doi.org/10.1038/nature25012.

Глaвa 7. Пищевые огрaничения

1 Most, J., Tosti, V., Redman, L. M., Fontana, L. 2017. “Calorie Restriction in Humans: An Update”. Ageing Research Reviews 39:36–45, https://doi.org/10.1016/j.arr.2016.08.005.

2 Hindhede, M. 1920. “The Effect of Food Restriction during War on Mortality in Copenhagen”. JAMA 74:381–82; Strom, A., Jensen, R. A. 1951. “Mortality from Circulatory Diseases in Norway 1940–1945”. Lancet 1:126–29, https://doi.org/10.1016/s0140–6736 (51) 91210-x.

3 Most et al. 2017.

4 Osborne, T. B., Mendel, L. B., Ferry, E. L. 1917. “The Effect of Retardation of Growth upon the Breeding Period and Duration of Life of Rats”. Science 45:294–95, https://doi.org/10.1126/science.45.1160.294.

5 Hansel, W. 2016. “Clive McCay: A Man Before His Time”. Endocrinology and Metabolic Syndrome 5:3, https://doi.org/10.4172/2161–1017.1000236.

6 Kopec, S. 1928. “On the Influence of Intermittent Starvation on the Longevity of the Imaginal Stage of Drosophila melanogaster”. Journal of Experimental Biology 5:204–11.

7 Greer, E. L., Brunet, A. 2009. “Different Dietary Restriction Regimens Extend Lifespan by Both In de pen dent and Overlapping Genetic Pathways in C. elegans”. Aging Cell 8:113–27, https://doi.org/10.1111/j.1474–9726.2009.00459.x.

8 Bonkowski, M. S., et al. 2009. “Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity”. PLOS One 4: e4567, https://doi.org/10.1371/journal.pone.0004567; Bonkowski, M. S., Rocha, J. S., Masternak, M. M., Al Regaiey, K. A., Bartke, A. 2006. “Targeted Disruption of Growth Hormone Receptor Interferes with the Beneficial Actions of Calorie Restriction”. Proceedings of the National Academy of Sciences of the USA 103:7901–5, https://doi.org/10.1073/pnas.0600161103.

9 Mattison, J. A., et al. 2017. “Caloric Restriction Improves Health and Survival of Rhesus Monkeys”. Nature Communications 8:14063, https://doi.org/10.1038/ncomms14063.

10 Mattison et al. 2017.

11 Mair, W., Goymer, P., Pletcher, S. D., Partridge, L. 2003. “Demography of Dietary Restriction and Death in Drosophila”. Science 301:1731–33.

12 Padamsey, Z., Katsanevaki, D., Dupuy, N., Rochefort, N. L. 2022. “Neocortex Saves Energy by Reducing Coding Precision during Food Scarcity”. Neuron 110:280–96.e210, https://doi.org/10.1016/j.neuron.2021.10.024.

13 Kauffman, A. L., Ashraf, J. M., Corces-Zimmerman, M. R., Landis, J. N., Murphy, C. T. 2010. “Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age”. PLOS Biology 8: e1000372, https://doi.org/10.1371/journal.pbio.1000372.

14 О дрозофилaх: Plaçais, P. Y., Preat, T. 2013. “To Favor Survival under Food Shortage, the Brain Disables Costly Memory”. Science 339:440–42, https://doi.org/10.1126/science.1226018. О мясных мухaх: Longden, K. D., Muzzu, T., Cook, D. J., Schultz, S. R., Krapp, H. G. 2014. “Nutritional State Modulates the Neural Processing of Visual Motion”. Current Biology 24:890–95, https://doi.org/10.1016/j.cub.2014.03.005.

15 Skorupa, D. A., Dervisefendic, A., Zwiener, J., Pletcher, S. D. 2008. “Dietary Composition Specifies Consumption, Obesity, and Lifespan in Drosophila melanogaster”. Aging Cell 7:478–90, https://doi.org/10.1111/j.1474–9726.2008.00400.x.

16 Babygirija, R., Lamming, D. W. 2021. “The Regulation of Healthspan and Lifespan by Dietary Amino Acids”. Translational Medicine of Aging 5:17–30, https://doi.org/10.1016/j.tma.2021.05.001.

17 Lopez-Torres, M., Barja, G. 2008. “Lowered Methionine Ingestion as Responsible for the Decrease in Rodent Mitochondrial Oxidative Stress in Protein and Dietary Restriction: Possible Implications for Humans”. Biochimica et Biophysica Acta 1780:1337–47, https://doi.org/10.1016/j.bbagen.2008.01.007; Pamplona, R., Barja, G. 2006. “Mitochondrial Oxidative Stress, Aging and Caloric Restriction: The Protein and Methionine Co

18 Grandison, R. C., Piper, M. D., Partridge, L. 2009. “Amino-Acid Imbalance Explains Extension of Lifespan by Dietary Restriction in Drosophila”. Nature 462:1061–64, https://doi.org/10.1038/nature08619; Zhou, G., et al. 2020. “Methionine Increases Yolk Production to Offset the Negative Effect of Caloric Restriction on Reproduction without Affecting Longevity in C. elegans”. Aging (Albany NY) 12:2680–97, https://doi.org/10.18632/aging.10 2770.

19 Richardson, N. E., et al. 2021. “Lifelong Restriction of Dietary Branched-Chain Amino Acids has Sex-Specific Benefits for Frailty and Lifespan in Mice”. Nature Aging 1:73–86, https://doi.org/10.1038/s43587-020-00006-2.

20 Lagiou, P., et al. 2007. “Low Carbohydrate-High Protein Diet and Mortality in a Cohort of Swedish Women”. Journal of Internal Medicine 261:366–74, https://doi.org/10.1111/j.1365–2796.2007.01774.x.